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How to pronounce topoisomerase

Say it like top-oh-eye-SAH-muh-rays. Topoisomerase has six syllables, and the main stress falls on the fourth one (SAH).

VoiceSpeed

Click the play button next to American or British to hear how to pronounce topoisomerase. Choose Slow to hear each sound clearly.

US American/ˌtɑpoʊˌaɪˈsɑməˌreɪs/top-oh-eye-SAH-muh-rays
UK British/ˌtɒpəʊˌaɪˈsɒməˌreɪs/top-oh-eye-SOM-uh-rays
  • top
  • oh
  • eye
  • SAH
  • muh
  • rays
  • Main stress
  • Lighter stress
  • Unstressed

Topoisomerase pronunciation, sound by sound

Read the parts left to right, then blend them together without pausing.

  1. topGive this part a little weight. The vowel is the "ah" in father.
  2. ohKeep this part quick and light. The vowel is the "o" in go.
  3. eyeGive this part a little weight. The vowel is the "i" in time.
  4. SAHSay this part loudest and longest. The vowel is the "ah" in father.
  5. muhKeep this part quick and light. The vowel is the relaxed "uh" in about.
  6. raysGive this part a little weight. The vowel is the "ay" in day.

American vs British pronunciation of topoisomerase

  • The short o is rounded in British English (as in "hot"), but open and unrounded in American English.
  • The long o starts further forward in British English, closer to "uh-oo" than the American "oh".

British respelling: top-oh-eye-SOM-uh-rays.

What does topoisomerase mean?

noun
  1. Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.

Where does topoisomerase come from?

From topo- + isomerase.

Words that rhyme with topoisomerase

Practicing rhymes is a quick way to lock in the vowel sound of topoisomerase.

Questions about saying topoisomerase

How do you pronounce topoisomerase?

Say top-oh-eye-SAH-muh-rays. The American pronunciation is /ˌtɑpoʊˌaɪˈsɑməˌreɪs/. In British English it is /ˌtɒpəʊˌaɪˈsɒməˌreɪs/. Press play above to hear it at normal speed or slowly.

How many syllables are in topoisomerase?

Topoisomerase has six syllables, and the main stress falls on the fourth one (SAH). Broken into parts: top · oh · eye · SAH · muh · rays.

Is topoisomerase pronounced differently in British English?

Yes. The short o is rounded in British English (as in "hot"), but open and unrounded in American English. The British form is /ˌtɒpəʊˌaɪˈsɒməˌreɪs/ (top-oh-eye-SOM-uh-rays).

Pronunciation from Wiktionary; meaning and origin adapted from Wiktionary (CC BY-SA 4.0).